Product Name :
Phospho-IRF3 (S386) Recombinant Rabbit Monoclonal Antibody [SU03-28]
Predicted band size :
47 kDa
Observed band size :
55 kDa
Synonyms:
IIAE7 antibody Interferon regulatory factor 3 antibody IRF 3 antibody IRF-3 antibody IRF3 antibody IRF3_HUMAN antibody MGC94729 antibody
Function :
Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor. IRF3 is a member of the interferon regulatory transcription factor (IRF) family. IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. The complex translocates into the nucleus for the transcriptional activation of interferons alpha and beta, and further interferon-induced genes.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic phospho-peptide corresponding to residues surrounding Ser386 of human IRF3.(R)-Tetrahydrofuran-3-carboxylic acid Chemscene
Species reactivity:
Human, Mouse
Verify application:
WB, IF-Cell, IF-Tissue
Coupling :
unconjugated
Clone number:
SU03-28
RRID:
AB_3069793
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.3-Butynoic acid In stock Aliquot store at -20℃ or -80℃.PMID:33706628 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 47 kDa
Positive control :
MCF7 treated with 100nM Calyculin A for 30 minutes whole cell lysate, NIH/3T3 treated with 100nM Calyculin A for 30 minutes cell lysate, MCF-7.