Product Name :
RTN3 Recombinant Rabbit Monoclonal Antibody [PSH0-40]
Predicted band size :
112.6 kDa
Observed band size :
100 kDa
Synonyms:
ASYIP antibody Neuroendocrine specific protein like 2 antibody Neuroendocrine-specific protein-like 2 antibody Neuroendocrine-specific protein-like II antibody NSP like protein II antibody NSP-like protein 2 antibody NSP-like protein II antibody NSPL2 antibody NSPLII antibody Reticulon 3 antibody 展开
Function :
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules.852875-99-1 Formula Acts also as an inflammation-resolving regulator by interacting with both TRIM25 and RIG-I/DDX58, subsequently impairing DDX58 ‘Lys-63’-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.Caffeine Impurity 7 web
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within human RTN3 aa 1-500 / 1,032.PMID:33746028
Species reactivity:
Human, Rat
Verify application:
WB, IF-Cell, FC
Coupling :
unconjugated
Clone number:
PSH0-40
RRID:
AB_3072459
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 112.6 kDa
Positive control :
HeLa cell lysate, HEK-293 cell lysate, U87-MG cell lysate, A549 cell lysate, SH-SY5Y cell lysate, PC-12 cell lysate, L6 cell lysate, human cerebellum tissue lysate, PC-12, HeLa.