Product Name :
TCF7L2/TCF4 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
bHLHb19 antibody Class B basic helix-loop-helix protein 19 antibody E2 2 antibody FECD3 antibody Immunoglobulin transcription factor 2 antibody ITF 2 antibody ITF-2 antibody ITF2 antibody ITF2_HUMAN antibody MGC149723 antibody 展开
Function :
TCF7L2 is a transcription factor influencing the transcription of several genes thereby exerting a large variety of functions within the cell. It is a member of the Wnt signaling pathway. Stimulation of the pathway leads to the association of β-catenin with BCL9, translocation to the nucleus, and association with TCF7L2, which in turn results in the activation of Wnt target genes, specifically repressing proglucagon synthesis in enteroendocrine cells. TCF7L2 is implicated in a large variety of diseases.Price of Fmoc-N-PEG24-acid Several single nucleotide polymorphisms are associated with type 2 diabetes. In European populations it was found to be a major determinant of type 2 risk. A frameshift mutation of TCF7L2 is implicated in colorectal cancer .Variants of the gene are most likely involved in many other cancer types
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide within N-terminalHuman TCF4 aa 1-50 / 619.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P, IF-Cell, FC
Coupling :
unconjugated
Clone number:
RRID:
AB_3073271
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Price of Pyrene-4,5,9,10-tetraone Aliquot store at -20℃.PMID:33645457 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 68 kDa
Positive control :
Hela, HepG2, HCT116, SW480, rat kidney tissue, human tonsil tissue, human colon cancer tissue, human breast cancer tissue.