Product Name :
xCT/SLC7A11 Mouse Monoclonal Antibody [A7C5]
Predicted band size :
55 kDa
Observed band size :
50 kDa
Synonyms:
Amino acid transport system xc xCT antibody antibody Amino acid transport system xc- antibody Calcium channel blocker resistance protein CCBR1 antibody Calcium channel blocker resistance protein CCBR1 antibody antibody CCBR1 antibody Cysteine/glutamate transporter antibody antibody Cystine/glutamate transporter antibody OTTHUMP00000164578 antibody SLC7A11 antibody Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 antibody 展开
Function :
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
293 cell line overexpressing SLC7A11.
Species reactivity:
Human, Mouse
Verify application:
WB, IHC-P, FC
Coupling :
unconjugated
Clone number:
A7C5
RRID:
AB_3071713
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
Store at +4℃ after thawing.Formula of 121553-38-6 Aliquot store at -20℃.4-Cyanobenzaldehyde Chemscene Avoid repeated freeze / thaw cycles.PMID:33620863
Storage buffer solution:
PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG2b
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 55 kDa
Positive control :
HT-29 cell lysate, A549 cell lysate, human pancreas tissue, A549, HT-29.