Product Name :
TdT Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
Deoxynucleotidyltransferase terminal antibody DNA nucleotidylexotransferase antibody DNTT antibody Nucleosidetriphosphate DNA deoxynucleotidylexotransferase antibody TDT antibody TDT_HUMAN antibody Terminal addition enzyme antibody Terminal deoxynucleotidyltransferase antibody Terminal deoxyribonucleotidyltransferase antibody Terminal transferase antibody
Function :
Terminal deoxynucleotidyltransferase (TdT) is a DNA polymerase expressed in immature lymphocytes of the thymus and bone marrow, as well as certain leukemic cells. The nuclear enzyme TdT plays a critical role in generating immune receptor diversity. During rearrangement of Ig and TCR V region genes, TdT catalyzes the addition of N nucleotides without a DNA template to V-D and D-J junctions in both Ig and TCR as well as the V-J junctions in the TCR (1–3). During the fetal and newborn period, TdT activity is absent, resulting in an N region-deficient Ag receptor repertoire significantly lacking in the diversity observed in the junctional regions of Igs and TCRs of adult animals
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide within Human TdT aa 460-509 / 509.
Species reactivity:
Human
Verify application:
WB
Coupling :
unconjugated
Clone number:
RRID:
AB_3068675
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.1438382-15-0 Data Sheet Aliquot store at -20℃.Tetrabutylammonium periodate Price Avoid repeated freeze / thaw cycles.PMID:33692169
Storage buffer solution:
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
58kDa
Positive control :
Jurkat