Product Name :
ZNF144 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
DNA binding protein Mel 18 antibody DNA-binding protein Mel-18 antibody Mel 18 antibody MGC10545 antibody PCGF 2 antibody PCGF2 antibody PCGF2_HUMAN antibody Polycomb group ring finger 2 antibody Polycomb group RING finger protein 2 antibody RING finger protein 110 antibody 展开
Function :
Transcriptional repressor. Binds specifically to the DNA sequence 5′-GACTNGACT-3′. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility. Is not functionally redundant with Bmi1; unlike Bmi1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex.Price of (R)-2-amino-1-phenylethan-1-ol
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from human Mel18/ZNF144 145-245
Species reactivity:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse
Verify application:
WB, ELISA, IHC-P, IF, ICC
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year.2,6-Pyridinedicarboxaldehyde manufacturer Avoid repeated freeze/thaw cycles.PMID:33685329 The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
38/60 KDa
Positive control :
Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle.