Product Name :
2′-O-Methylcytidine (CAS 2140-72-9)
Synonym :
Application :
2′-O-Methylcytidine is a cytidine analog
CAS:
2140-72-9
Purity:
≥98%
Molecular Weight:
257.24
Formula :
C10H15N3O5
Physical state:
Solid
solubility :
Soluble in water (Slightly), DMSO, and methanol.
Shipping Condition :
Store at -20° C
Melting point:
250-255° C
SMILES:
CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=NC2=O)N)CO)O
References:
:Catabolism of the methyl derivatives of adenosine and cytidine in staphylococci. | Krasuski, A. and Marlewski, M. 1999. Microbios. 98: 149-57. PMID: 10464951Identification of a modified nucleoside in Escherichia coli tRNA1Ser as 2′-O-methylcytidine. | Yamada, Y. and Ishikura, H. 1975. Biochim Biophys Acta. 402: 285-7. PMID: 1100116Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2′-O-methylcytidine at position 56 of tRNA. | Kuratani, M., et al. 2008. J Mol Biol. 375: 1064-75. PMID: 18068186Osmium Tag for Post-transcriptionally Modified RNA.163452-79-7 web | Debnath, TK.BuyFmoc-Gly-OH and Okamoto, A.PMID:33560479 2018. Chembiochem. 19: 1653-1656. PMID: 29799158Identification and Quantification of Modified Nucleosides in Saccharomyces cerevisiae mRNAs. | Tardu, M., et al. 2019. ACS Chem Biol. 14: 1403-1409. PMID: 31243956Structural and Energetic Effects of O2′-Ribose Methylation of Protonated Pyrimidine Nucleosides. | He, CC., et al. 2019. J Am Soc Mass Spectrom. 30: 2318-2334. PMID: 31435890Metabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS. | Neef, SK., et al. 2020. Metabolites. 10: PMID: 33271860Development of a highly sensitive method for the quantitative analysis of modified nucleosides using UHPLC-UniSpray-MS/MS. | Kogaki, T., et al. 2021. J Pharm Biomed Anal. 197: 113943. PMID: 33601155Serum metabolomics analysis for the progression of esophageal squamous cell carcinoma. | Li, X., et al. 2021. J Cancer. 12: 3190-3197. PMID: 33976728Mass Spectrometry-Based Targeted Serum Monomethylated Ribonucleosides Profiling for Early Detection of Breast Cancer. | Fang, Z., et al. 2021. Front Mol Biosci. 8: 741603. PMID: 34513933Simultaneous Determination of Methylated Nucleosides by HILIC-MS/MS Revealed Their Alterations in Urine from Breast Cancer Patients. | Fang, Z., et al. 2022. Metabolites. 12: PMID: 362958752′-O-methylation of adenosine, guanosine, uridine, and cytidine in RNA of isolated rat liver nuclei. | al-Arif, A. and Sporn, MB. 1972. Proc Natl Acad Sci U S A. 69: 1716-9. PMID: 4340155Synthesis of 2′-O-methyluridine, 2′-O-methylcytidine and their relating compounds. | Furukawa, Y., et al. 1965. Chem Pharm Bull (Tokyo). 13: 1273-8. PMID: 5864715