Product Name :
2′-Deoxy-2′,2′-difluorocytidine (CAS 95058-81-4)
Synonym :
Gemcitabine
Application :
2′-Deoxy-2′,2′-difluorocytidine is an irreversible inactivator of bacterial ribonucleoside diphosphate reductase
CAS:
95058-81-4
Purity:
≥98%
Molecular Weight:
263.199
Formula :
C9H11F2N3O4
Physical state:
Solid
solubility :
Soluble in ethanol (~0.25 mg/ml), DMSO (15 mg/ml at 25° C), DMF (~0.1 mg/ml), water (<1 mg/ml at 25° C), and PBS pH 7.2 (~2 mg/ml).
Shipping Condition :
Store at -20° C
Melting point:
200-224° C (Predicted)
SMILES:
OC[C@H]1O[C@@H](n2ccc(N)nc2=O)C(F)(F)C1O
References:
:2′-Deoxy-2′-methylenecytidine and 2′-deoxy-2′,2′-difluorocytidine 5′-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase. | Baker, CH., et al. 1991. J Med Chem. 34: 1879-84. PMID: 2061926Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity. | Lin, KH., et al. 2019. Cell Metab. 29: 1217-1231.e7.Boc-NH-C6-Br In stock PMID: 30773463Downregulation of miR-183 inhibits the growth of PANC-1 pancreatic cancer cells in vitro and in vivo, and increases chemosensitivity to 5-fluorouracil and gemcitabine.Formula of 1,3,5-Tribromo-2,4,6-trimethylbenzene | Yang, X.PMID:33629634 , et al. 2019. Exp Ther Med. 17: 1697-1705. PMID: 30783438Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma. | Msaouel, P., et al. 2020. Cancer Cell. 37: 720-734.e13. PMID: 32359397MiR-9-3p regulates the biological functions and drug resistance of gemcitabine-treated breast cancer cells and affects tumor growth through targeting MTDH. | Wang, Y., et al. 2021. Cell Death Dis. 12: 861. PMID: 34552061ICAM-1 Targeted Drug Combination Nanoparticles Enhanced Gemcitabine-Paclitaxel Exposure and Breast Cancer Suppression in Mouse Models. | Zhu, L., et al. 2021. Pharmaceutics. 14: PMID: 35056985